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B4galt1tm1Yiw
Targeted Allele Detail
Nomenclature
Symbol: B4galt1tm1Yiw
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:2450889
Synonyms: Beta4GalT-I-, GalT-
Gene: B4galt1  Location: Chr4:40804602-40854005 bp, - strand  Genetic Position: Chr4, 20.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40026
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a PGK-neo cassette inserted by homologous recombination. The deleted exon contained the start codon and encoded the golgi retention signal. While the targeting vector was designed to disrupt both long and short isoforms, assays showed residual endogenous activity (less than 5% of wild-type levels) in homozygous mutant mice. (J:40026)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any B4galt1 Mutation:  29 strains or lines available
References
Original:  J:40026 Asano M, et al., Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J. 1997 Apr 15;16(8):1850-7
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory