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Ncoa6tm1Pera
Targeted Allele Detail
Nomenclature
Symbol: Ncoa6tm1Pera
Name: nuclear receptor coactivator 6; targeted mutation 1, Per Antonson
MGI ID: MGI:2450859
Synonyms: Rap250-
Gene: Ncoa6  Location: Chr2:155390665-155473894 bp, - strand  Genetic Position: Chr2, 77.26 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81818
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 7 and 8 with a neomycin resistance cassette via homologous recombination, resulting in deletion of the nuclear receptor box and transactivation domain. Absence of gene expression was verified by RT-PCR analysis of fibroblasts derived from homozygous mutant embryos. (J:81818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncoa6 Mutation:  57 strains or lines available
References
Original:  J:81818 Antonson P, et al., Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol. 2003 Feb;23(4):1260-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory