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Targeted Allele Detail
Symbol: Grip1tm1Paw
Name: glutamate receptor interacting protein 1; targeted mutation 1, Anthony Pawson
MGI ID: MGI:2449094
Synonyms: GRIP1-
Gene: Grip1  Location: Chr10:119454034-120087261 bp, + strand  Genetic Position: Chr10, 67.33 cM, cytoband D2
Development of a severe bullous disorder in Grip1tm1Paw/Grip1tm1Paw embryos

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:79476
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.6 kb fragment was replaced with a beta-galactosidase gene followed by a floxed neo gene. The deleted region included a 3' portion of the exon encoding the first PDZ domain. No full length protein was detected by Western blot analysis of protein extracts obtained from homozygous mutant embryos. Beta-galactosidase staining indicated that the reporter gene was expressed via the endogenous promoter. (J:79476)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grip1 Mutation:  26 strains or lines available
Original:  J:79476 Bladt F, et al., Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6816-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory