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Jak1tm1Rds
Targeted Allele Detail
Nomenclature
Symbol: Jak1tm1Rds
Name: Janus kinase 1; targeted mutation 1, Robert D Schreiber
MGI ID: MGI:2448928
Synonyms: Jak1-
Gene: Jak1  Location: Chr4:101152367-101265282 bp, - strand  Genetic Position: Chr4, 46.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47300
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 1 and 2 and 1.6 kb of 5' upstream sequence with a neomycin resistance cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of embryonic fibroblasts derived from homozygous mutant embryos. (J:47300)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak1 Mutation:  11 strains or lines available
References
Original:  J:47300 Rodig SJ, et al., Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 1998 May 1;93(3):373-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory