Phenotypes associated with this allele

• Allele Symbol: Jak1^tm1Rds
• Allele Name: targeted mutation 1, Robert D Schreiber
• Allele ID: MGI:2448928
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak1^tm1Rds/Jak1^tm1Rds	involves: 129	MGI:3583257

Genotype
MGI:3583257

hm1

• Allelic Composition: Jak1^tm1Rds/Jak1^tm1Rds
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:47300 )

• homozygous pups all die within 24 hours of birth

immune system

small thymus ( J:47300 )

• severely reduced in size

decreased thymocyte number ( J:47300 )

abnormal lymphopoiesis ( J:47300 )

abnormal B cell differentiation ( J:47300 )

arrested B cell differentiation ( J:47300 )

• pro-B to Pre-B cell transition is blocked

abnormal T cell differentiation ( J:47300 )

increased double-negative T cell number ( J:47300 )

decreased B cell number ( J:47300 )

• double positive B cells are reduced 40 fold

• B220+ IgM- B cell precursors are reduced 7-10 fold

growth/size/body

decreased body weight ( J:47300 )

• newborns weigh 40% less than controls

behavior/neurological

abnormal suckling behavior ( J:47300 )

• fail to nurse

hematopoietic system

small thymus ( J:47300 )

• severely reduced in size

decreased thymocyte number ( J:47300 )

abnormal lymphopoiesis ( J:47300 )

abnormal B cell differentiation ( J:47300 )

arrested B cell differentiation ( J:47300 )

• pro-B to Pre-B cell transition is blocked

abnormal T cell differentiation ( J:47300 )

increased double-negative T cell number ( J:47300 )

decreased B cell number ( J:47300 )

• double positive B cells are reduced 40 fold

• B220+ IgM- B cell precursors are reduced 7-10 fold

endocrine/exocrine glands

small thymus ( J:47300 )

• severely reduced in size

decreased thymocyte number ( J:47300 )