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Tg(MT-HGFSF)18Lmb
Transgene Detail
Nomenclature
Symbol: Tg(MT-HGFSF)18Lmb
Name: transgene insertion 18, Glenn Merlino
MGI ID: MGI:2447463
Synonyms: MT-HGF/SF, SF/HGF, Tg HFG
Transgene: Tg(Mt-HGFSF)18Lmb  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (random, expressed)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Nine founders carrying between 7-27 copies of the transgene were created. Transgenic animals over-expressed the transgene 3-fold to 50-fold. The line 18 transgene, Tg(Mt-HGFSF)18Lmb, is also called MT-HGF/SF.
Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)
Phenotypic Similarity to Human Syndrome: Rhabdomyosarcoma in mice homozygous for Cdkn2atm1Rdp and hemizygous for this allele (J:79704)

References
Original:  J:34022 Takayama H, et al., Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5866-71
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory