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Tg(MT-HGFSF)18Lmb
Transgene Detail
Nomenclature
Symbol: Tg(MT-HGFSF)18Lmb
Name: transgene insertion 18, Glenn Merlino
MGI ID: MGI:2447463
Synonyms: MT-HGF/SF, SF/HGF, Tg HFG
Transgene: Tg(Mt-HGFSF)18Lmb  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene consists of a mouse metallothionein 1 promoter, the entire mouse hepatocyte growth factor cDNA sequence, a human growth hormone polyadenylation site, and mouse Mt1 5' and 3' flanking regions. Northern blot analysis showed transgene expression in all adult transgenic tissues examined. ELIZA assay showed overexpression of transgene product in urine and serum samples. (J:34022)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Nine founders carrying between 7-27 copies of the transgene were created. Transgenic animals over-expressed the transgene 3-fold to 50-fold. The line 18 transgene, Tg(Mt-HGFSF)18Lmb, is also called MT-HGF/SF.
Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)

References
Original:  J:34022 Takayama H, et al., Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5866-71
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory