Tg(Mt1-Hgf)18Lmb
Transgene Detail

Summary

• Symbol: Tg(Mt1-Hgf)18Lmb
• Name: transgene insertion 18, Glenn Merlino
• MGI ID: MGI:2447463
• Synonyms: MT-HGF/SF, SF/HGF, Tg HFG, Tg(Mt1-HGFSF)18Lmb, Tg(Mt-HGFSF)18Lmb
• Transgene: Tg(Mt1-Hgf)18Lmb Location: unknown
• Alliance: Tg(Mt1-Hgf)18Lmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Hgf)18Lmb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hgf (MGI:96079)

• Tg(Mt1-Hgf)18Lmb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mt1 (MGI:97171)

• Mutation details: The transgene consists of a mouse metallothionein 1 promoter, the entire mouse hepatocyte growth factor cDNA sequence, a human growth hormone polyadenylation site, and mouse Mt1 5' and 3' flanking regions. Northern blot analysis showed transgene expression in all adult transgenic tissues examined. ELIZA assay showed overexpression of transgene product in urine and serum samples. (J:34022)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-Hgf)18Lmb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Nine founders carrying between 7-27 copies of the transgene were created. Transgenic animals over-expressed the transgene 3-fold to 50-fold. The line 18 transgene, Tg(Mt-HGFSF)18Lmb, is also called MT-HGF/SF.
Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)

References

• Original: J:34022 Takayama H, et al., Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5866-71
• All: 16 reference(s)