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Sox6tm1Vlf
Targeted Allele Detail
Nomenclature
Symbol: Sox6tm1Vlf
Name: SRY (sex determining region Y)-box 6; targeted mutation 1, Veronique Lefebvre
MGI ID: MGI:2447148
Synonyms: Sox6lacZ
Gene: Sox6  Location: Chr7:115470872-116038796 bp, - strand  Genetic Position: Chr7, 61.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80666
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a lacZ-neo-derived cassette into the second coding exon of the gene. Absence of gene expression in homozygous animals was confirmed by Northern blot analysis of whole embryo RNA. X-gal staining of mutant embryos revealed lacZ expression in cartilage tissue. (J:80666)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 59 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox6 Mutation:  5 strains or lines available
References
Original:  J:80666 Smits P, et al., The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory