All Phenotypes Sox6<tm1Vlf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox6^tm1Vlf
targeted mutation 1, Veronique Lefebvre
MGI:2447148

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox6^tm1Vlf/Sox6^tm1Vlf	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653475
cn2	Sox5^tm1Vlf/Sox5^tm1Vlf Sox6^tm1Vlf/Sox6^tm2.1Vlf Tg(Col2a1-cre)1Bhr/0	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3641207
cx3	Sox5^tm1Vlf/Sox5⁺ Sox6^tm1Vlf/Sox6⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3029222
cx4	Sox5^tm1Vlf/Sox5^tm1Vlf Sox6^tm1Vlf/Sox6^tm1Vlf	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653476

Allelic Composition	Sox6^tm1Vlf/Sox6^tm1Vlf
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox6^tm1Vlf mutation (0 available); any Sox6 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:80666 )

• animals surviving after birth died within two weeks

neonatal lethality, incomplete penetrance ( J:80666 )

• incomplete penetrance; most animals die after birth due to respiratory failure

growth/size/body

decreased body size ( J:80666 )

• severe, noted in animals surviving after birth

respiratory system

respiratory distress ( J:80666 )

• evident at birth

respiratory failure ( J:80666 )

• failure to breathe

Allelic Composition	Sox5^tm1Vlf/Sox5^tm1Vlf Sox6^tm1Vlf/Sox6^tm2.1Vlf Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5^tm1Vlf mutation (0 available); any Sox5 mutation (45 available)
Sox6^tm1Vlf mutation (0 available); any Sox6 mutation (58 available)
Sox6^tm2.1Vlf mutation (1 available); any Sox6 mutation (58 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cartilage development ( J:110147 )

• poorly developed cartilage similar to double homozygous mice

Allelic Composition	Sox5^tm1Vlf/Sox5⁺ Sox6^tm1Vlf/Sox6⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:80666 )

• slightly smaller and leaner than controls

skeleton

short sternum ( J:80666 )

• slightly shorter

abnormal bone mineralization ( J:80666 )

• sternum appeared irregularly mineralized

Allelic Composition	Sox5^tm1Vlf/Sox5^tm1Vlf Sox6^tm1Vlf/Sox6^tm1Vlf
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:80666 )

• die approximately at E16.5 from congestive heart failure

cardiovascular system

abnormal blood circulation ( J:80666 )

• accumulation of blood in liver, inferior vena cava and right atrium of the heart

craniofacial

short snout ( J:80666 )

growth/size/body

short snout ( J:80666 )

decreased body length ( J:80666 )

• short trunk

distended abdomen ( J:80666 )

homeostasis/metabolism

edema ( J:80666 )

• generalized edema noted

limbs/digits/tail

short limbs ( J:80666 )

short tail ( J:80666 )

skeleton

abnormal thoracic cage morphology ( J:80666 )

• incomplete thoracic cage

short vertebral column ( J:80666 )

• short vertebral column

abnormal cartilage morphology ( J:80666 )

abnormal chondrocyte morphology ( J:80666 )

• cells develop normally to the prechondrocyte stage, but fail to differentiate into mature chondroblasts

absent cartilage ( J:80666 )

chondrodystrophy ( J:80666 )

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