About   Help   FAQ
Bmd6C3H/HeJ
QTL Variant Detail
Nomenclature
QTL variant: Bmd6C3H/HeJ
Name: bone mineral density 6; C3H/HeJ
MGI ID: MGI:2447014
QTL: Bmd6  Location: Chr2:168936377-168936499 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 88.99 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C3H/HeJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased femoral BMD compared to C57BL/6J. (J:78754)
Inheritance:    Other (see notes)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes
Bmd6 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78754

Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd6 mapped to 86.3 cM on mouse Chromosome 6 with a peak LOD=3.14 at D2Mit456 in linkage to femoral BMD. C3H/HeJ-derived alleles confer an additively-inherited increase in BMD at Bmd6.

References
Original:  J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/11/2020
MGI 6.14
The Jackson Laboratory