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Irf9tm1Ttg
Targeted Allele Detail
Nomenclature
Symbol: Irf9tm1Ttg
Name: interferon regulatory factor 9; targeted mutation 1, Tadatsugu Taniguchi
MGI ID: MGI:2446102
Synonyms: IRF-9-, p48-
Gene: Irf9  Location: Chr14:55603985-55610030 bp, + strand  Genetic Position: Chr14, 28.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77456
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo exons encoding the DNA binding domain (amino acids 1 through 121) were replaced by a neomycin resistance cassette. Electrophoretic mobility shift assay indicated the loss of Ifna induced activity. (J:77456)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Irf9 Mutation:  29 strains or lines available
References
Original:  J:77456 Kimura T, et al., Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Genes Cells. 1996 Jan;1(1):115-24
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory