Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf9tm1Ttg mutation
(2 available);
any
Irf9 mutation
(40 available)
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immune system
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• CpG-A-induced production of interferon-alpha was abolished
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skeleton
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• mice exhibit a 40% decreased in bone volume in the trabecular bone compared to in wild-type mice
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Allelic Composition |
Irf9tm1Ttg/Irf9tm1Ttg
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Genetic Background |
either: (involves: C57BL/6 * CBA * ICR) or (involves: A/J * C57BL/6 * CBA) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf9tm1Ttg mutation
(2 available);
any
Irf9 mutation
(40 available)
|
|
|
immune system
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• antivirus responses induced by Ifn alpha and Ifn gamma were impaired
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immune system
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• Newcastle disease virus infected MEFs had undetectable interferon-alpha/beta activity, indicating that mutant MEFs are incapable of responding to infection
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integument
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• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice
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