Del(2Hoxd12-Hoxd13)6Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd12-Hoxd13)6Ddu
• Name: deletion, Chr 2, Denis Duboule 6
• MGI ID: MGI:2445999
• Synonyms: Del6Ddu, HoxD^{RXII-del(13-12)}, Hoxd^tm9Ddu
• Gene: Del(2Hoxd12-Hoxd13)6Ddu Location: Chr2:74498654-74508049 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80084
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd12-Hoxd13)6Ddu involves 2 genes/genome features (Hoxd13, Hoxd12) View all
• Mutation details: Hoxd13, Hoxd 12, and regions X, XI, and XII were deleted via trans-allelic meiotic recombination (TAMERE). The deletion was accomplished by recombination of a single loxP site in the intergenic region between Evx2 and Hoxd13 that had replaced region XII (Evx2/Hoxd13^tm3.1Ddu) and a single loxP on the opposite chromosome 303 bp upstream of a 261 bp deletion of region X (Hoxd^tm4.1Ddu). (J:80084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd12-Hoxd13)6Ddu Mutation: 0 strains or lines available

References

• Original: J:80084 Kmita M, et al., Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Development. 2002 Dec;129(23):5521-8
• All: 2 reference(s)