Evx2^tm3.1Ddu
Targeted Allele Detail

Summary

• Symbol: Evx2^tm3.1Ddu
• Name: even-skipped homeobox 2; targeted mutation 3.1, Denis Duboule
• MGI ID: MGI:2445972
• Synonyms: EvD^GE3, Evx2/Hoxd13^tm1.1Ddu, L1
• Gene: Evx2 Location: Chr2:74483335-74489901 bp, - strand Genetic Position: Chr2, 44.13 cM
• Alliance: Evx2^tm3.1Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37211
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The floxed neo cassette inserted upstream of Evx2 was excised via in vivo cre mediated recombination. The reading frames of Evx2 and Hoxd13 remained interrupted by stop codons at bp 110 and 58, respectively. (J:37211)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evx2 Mutation: 19 strains or lines available

Notes

This allele exists only in mice carrying Hoxd13^tm3.1Ddu

References

• Original: J:37211 Herault Y, et al., Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 1996 Dec 2;15(23):6727-38
• All: 1 reference(s)