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Targeted Allele Detail
Symbol: Atf4tm1Aki
Name: activating transcription factor 4; targeted mutation 1, Shizuo Akira
MGI ID: MGI:2445679
Synonyms: ATF4(-)
Gene: Atf4  Location: Chr15:80255184-80257540 bp, + strand  Genetic Position: Chr15, 37.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:56007
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details0.8 kb of sequence encoding the basic leucine zipper was deleted by homologous recombination of a construct containing a neomycin selection cassette. Transcript was undetected by Northern blot analysis of homozygous mutant mice. (J:56007)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf4 Mutation:  13 strains or lines available
Original:  J:56007 Tanaka T, et al., Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells. 1998 Dec;3(12):801-10
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory