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Targeted Allele Detail
Symbol: Yy1tm1Yshi
Name: YY1 transcription factor; targeted mutation 1, Yang Shi
MGI ID: MGI:2445451
Synonyms: YY1-, Yy1delta
Gene: Yy1  Location: Chr12:108792973-108816632 bp, + strand  Genetic Position: Chr12, 59.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:57857
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 1 and the proximal promoter region was replaced with a neomycin selection cassette via homologous recombination. The deleted region encoded 227 of the 414 amino acids in the endogenous protein. No protein was detected in homozygous mutant embryos by immunostaining. (J:57857)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yy1 Mutation:  20 strains or lines available
Original:  J:57857 Donohoe ME, et al., Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999 Oct;19(10):7237-44
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory