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Targeted Allele Detail
Symbol: Hba/Nprl3tm1Wgw
Name: nitrogen permease regulator-like 3; targeted mutation 1, William G Wood
MGI ID: MGI:2445391
Synonyms: floxed mHS -26-, Maretm1Wgw, Nprl3tm1Wgw
Gene: Nprl3  Location: Chr11:32225628-32267707 bp, - strand  Genetic Position: Chr11, 18.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:80121
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsA 1312 bp region of the regulatory element (HS -26) lying within an intron of the Nprl3 gene containing transcription factor binding elements for the mouse alpha-globin genes was replaced with a floxed PGK-neo cassette via homologous recombination. Expression of the Nprl3 gene was severely down-regulated although the open reading frame of the gene was not disrupted. (J:80121)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nprl3 Mutation:  17 strains or lines available
Original:  J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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