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Dvl2tm1Awb
Targeted Allele Detail
Nomenclature
Symbol: Dvl2tm1Awb
Name: dishevelled segment polarity protein 2; targeted mutation 1, Anthony Wynshaw-Boris
MGI ID: MGI:2429760
Synonyms: Dvl2-
Gene: Dvl2  Location: Chr11:70000595-70012301 bp, + strand  Genetic Position: Chr11, 42.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79834
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette inserted by homologous recombination replaced a portion of exon 2 and all of exons 3 through 6. Western blot analysis of homozygous mutant brain lysates indicated an absence of protein. (J:79834)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dvl2 Mutation:  26 strains or lines available
References
Original:  J:79834 Hamblet NS, et al., Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec;129(24):5827-38
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory