Disp1^tm1Ptch
Targeted Allele Detail

Summary

• Symbol: Disp1^tm1Ptch
• Name: dispatched RND transporter family member 1; targeted mutation 1, Pao-Tien Chuang
• MGI ID: MGI:2429759
• Synonyms: Disp -, DispDelta E8
• Gene: Disp1 Location: Chr1:182867830-183003086 bp, - strand Genetic Position: Chr1, Syntenic
• Alliance: Disp1^tm1Ptch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79831
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 8 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region putatively encode all 12 predicted transmembrane domains. (J:79831)

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disp1 Mutation: 61 strains or lines available

Notes

Authors in J:79831 indicate that Disp1^tm1Ptch homozygotes exhibit gross morphological features that are nearly identical to those observed in Smo^tm1Amc mutant embryos, the model for complete loss of hedgehog signaling signaling activity (see J:70021).

References

• Original: J:79831 Kawakami T, et al., Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
• All: 1 reference(s)