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M6prtm1Psa
Targeted Allele Detail
Nomenclature
Symbol: M6prtm1Psa
Name: mannose-6-phosphate receptor, cation dependent; targeted mutation 1, Paul Saftig
MGI ID: MGI:2429535
Synonyms: MPR46 -
Gene: M6pr  Location: Chr6:122308720-122317680 bp, + strand  Genetic Position: Chr6, 57.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:16151
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 3 was disrupted by the insertion of a neomycin selection cassette. Expression was undetected by Northern and Western blot analysis various tissues obtained from homozygous mutant mice. (J:16151)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any M6pr Mutation:  13 strains or lines available
References
Original:  J:16151 Koster A, et al., Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J. 1993 Dec 15;12(13):5219-23
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory