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Targeted Allele Detail
Symbol: M6prtm1Psa
Name: mannose-6-phosphate receptor, cation dependent; targeted mutation 1, Paul Saftig
MGI ID: MGI:2429535
Synonyms: MPR46 -
Gene: M6pr  Location: Chr6:122308720-122317680 bp, + strand  Genetic Position: Chr6, 57.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:16151
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 3 was disrupted by the insertion of a neomycin selection cassette. Expression was undetected by Northern and Western blot analysis various tissues obtained from homozygous mutant mice. (J:16151)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any M6pr Mutation:  20 strains or lines available
Original:  J:16151 Koster A, et al., Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J. 1993 Dec 15;12(13):5219-23
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory