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Transgene Detail
Symbol: Tg(MMTV-TGFBR2)7Hlm
Name: transgene insertion 7, Harold L Moses
MGI ID: MGI:2429406
Synonyms: MMTV-DNIIR-7, TGF-betaRIIDN
Transgene: Tg(MMTV-TGFBR2)7Hlm  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(MMTV-TGFBR2)7Hlm expresses 1 gene
Mutation detailsA human cDNA encoding a carboxy-terminally truncated TGFBR2 was adjoined to an MMTV regulatory region. While the encoded receptor contains the complete extracellular and transmembrane domains and is therefore capable of ligand binding and and interacting with type 1 receptors, it lacks the kinase domain. Expression was driven in mammary epithelial cells by the MMTV LTR promoter/enhancer. Transgenic expression was verified by Northern blot analysis. (J:46432)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:46432 Gorska AE, et al., Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ. 1998 Mar;9(3):229-38
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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