F2rl1^tm1Mslb
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm1Mslb
• Name: F2R like trypsin receptor 1; targeted mutation 1, Mary Stevens
• MGI ID: MGI:2389587
• Synonyms: F2rl1^tm1Nwb, PAR-2^-, PAR2ko
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm1Mslb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79757
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a construct containing hygromycin and neomycin selection genes. Transcript was undetected by Northern blot analysis of liver tissue obtained from homozygous mutant mice. (J:79757)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying F2rl1^tm1Mslb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 58 strains or lines available

References

• Original: J:79757 Schmidlin F, et al., Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol. 2002 Nov 1;169(9):5315-21
• All: 59 reference(s)