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QTL Variant Detail
QTL variant: Lprm3C3H/HeJ
Name: lymphoproliferation modifier 3; C3H/HeJ
MGI ID: MGI:2389371
QTL: Lprm3  Location: Chr14:87983788-87983908 bp  Genetic Position: Chr14, cM position of peak correlated region/allele: 44.17 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3H/HeJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers glomerulonephritis susceptibility compared to MRL/MpJ.
Inheritance:    Dominant

Mapping and Phenotype information for this QTL, its variants and associated markers


82 MRL/MpJ-Tnfrsf6lpr x (MRL/MpJ-Tnfrsf6lpr x C3.MRL-Tnfrsf6lpr)F1 backcross animals were used to identify QTLs modifying the lpr (lymphoproliferation) mutant phenotype. Genotyping was performed with 76 microsatellite markers covering 84% of the mouse genome at an average spacing of 20 cM. The MRL/MpJ-Tnfrsf6lpr parental strain is susceptible to developing glomerulonephritis (98.2%) and vasculitis (86%) whereas the C3.MRL-Tnfrsf6lpr strain is resistant (0%) for both phenotypes. (MRL/MpJ-Tnfrsf6lpr x C3.MRL-Tnfrsf6lpr)F1 animals are resistant to glomerulonephritis (3%) and vasculitis (18%) development. Both strains exhibit lymph node swelling and splenomegaly in varying degrees. A QTL associated with vasculitis susceptibility, Lprm1 (P = 0.0009 at D4Mit178; 35.5 cM), maps to mouse chromosome 4 from 34 cM - 36 cM. MRL/MpJ-Tnfrsf6lpr-derived alleles contribute recessively inherited susceptibility to vasculitis at this locus. However, MRL/MpJ-Tnfrsf6lpr-derived alleles at Lprm2 (P = 0.0001 at D3Mit16; 66.2 cM), a QTL mapping to mouse chromosome 3 from 64 cM - 66 cM, confers female-specific recessively inherited vasculitis resistance. A possible candidate gene for Lprm1 is Tlr4 (the lps gene) at 33 cM. Lprm1 also maps near Nba1 (Drake, J:23719) and Sle2 (Morel, J:25006). Lprm3 (P = 0.0004 at D14Mit195; 44.3 cM), a QTL associated with glomerulonephritis resistance, maps to mouse chromosome 14 from 30 cM - 63 cM. MRL/MpJ-Tnfrsf6lpr-derived alleles at this locus confer recessively inherited glomerulonephritis resistance. Lprm4 (P = 0.0006 at D5Mit23; 54 cM) is associated with susceptibility to splenomegaly and maps to mouse chromosome 5 from 41 cM - 54 cM. MRL/MpJ-Tnfrsf6lpr-derived alleles at this locus confer recessively inherited splenomegaly susceptibility. Lprm5 (P = 0.0001 at D16Mit3; 21 cM) is associated with anti-dsDNA antibody titer and maps to mouse chromosome 16 from 21 cM - 38 cM. MRL/MpJ-Tnfrsf6lpr-derived alleles at this locus confer recessively inherited high antibody titers.

Original:  J:44625 Wang Y, et al., Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol. 1997 Dec;151(6):1791-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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