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Targeted Allele Detail
Symbol: Hoxd3tm2Mrc
Name: homeobox D3; targeted mutation 2, Mario R Capecchi
MGI ID: MGI:2388512
Synonyms: Hoxd3-, Hoxd3null
Gene: Hoxd3  Location: Chr2:74711927-74748442 bp, + strand  Genetic Position: Chr2, 44.13 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:60296
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by insertion of a self-excising neomycin resistance cassette into exon 2. Following removal of the neo cassette, 249 bp of endogenous exon 2 sequences were replaced with a single loxP site. (J:60296)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd3 Mutation:  7 strains or lines available
Original:  J:60296 Greer JM, et al., Maintenance of functional equivalence during paralogous Hox gene evolution [see comments]. Nature. 2000 Feb 10;403(6770):661-5
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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