Phenotypes associated with this allele

• Allele Symbol: Hoxd3^tm2Mrc
• Allele Name: targeted mutation 2, Mario R Capecchi
• Allele ID: MGI:2388512
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd3^tm2Mrc/Hoxd3^tm2Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3836909
ht2	Hoxd3^tm2Mrc/Hoxd3^tm3(Hoxa3)Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3836911
cx3	Hoxa3^tm3Mrc/Hoxa3^tm3Mrc Hoxd3^tm2Mrc/Hoxd3^tm2Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3836914

Genotype
MGI:3836909

hm1

• Allelic Composition: Hoxd3^tm2Mrc/Hoxd3^tm2Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

absent arcus anterior ( J:60296 )

• lack anterior arch

absent odontoid process ( J:60296 )

• lack dens

Genotype
MGI:3836911

ht2

• Allelic Composition: Hoxd3^tm2Mrc/Hoxd3^{tm3(Hoxa3)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

abnormal cervical atlas morphology ( J:60296 )

• partially restored

abnormal arcus anterior morphology ( J:60296 )

• anterior arch sometimes incomplete

abnormal odontoid process morphology ( J:60296 )

• partially restored

fusion of atlas and odontoid process ( J:60296 )

• dens of sometimes fused to the anterior arch of the atlas

Genotype
MGI:3836914

cx3

• Allelic Composition: Hoxa3^tm3Mrc/Hoxa3^tm3Mrc; Hoxd3^tm2Mrc/Hoxd3^tm2Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

abnormal neuronal migration ( J:86041 )

• migration of facial branchiomotor neurons from r6 to r7

abnormal somatic motor system morphology ( J:86041 )

• ectopic appearance of facial branchiomotor neurons in r6

cellular

abnormal neuronal migration ( J:86041 )

• migration of facial branchiomotor neurons from r6 to r7