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Targeted Allele Detail
Symbol: Tnfrsf13btm1Rjb
Name: tumor necrosis factor receptor superfamily, member 13b; targeted mutation 1, Richard J Bram
MGI ID: MGI:2388136
Synonyms: taci-
Gene: Tnfrsf13b  Location: Chr11:61126755-61149372 bp, + strand  Genetic Position: Chr11, 37.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:69474
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 2 exons and flanking intronic sequences were deleted and replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunoprecipitation immunoblot analysis of splenocyte proteins. (J:69474)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf13b Mutation:  1 strain or line available
Original:  J:69474 von Bulow GU, et al., Regulation of the T-independent humoral response by TACI. Immunity. 2001 May;14(5):573-82
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory