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Igh-Jtm1Jkbv
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm1Jkbv
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Aya Jakobovits
MGI ID: MGI:2388068
Synonyms: deltaJH
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70038
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe entire Igh-J region and a flanking DQ52 gene segment was deleted and replaced with a neomycin resistance gene via homologous recombination. Homozygous mutant animals were confirmed by Southern blot analysis. (J:70038)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
Notes
This allele is used in the Xenomouse strains.
References
Original:  J:70038 Jakobovits A, et al., Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2551-5
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/03/2022
MGI 6.19
The Jackson Laboratory