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Targeted Allele Detail
Symbol: Nodaltm3Rob
Name: nodal; targeted mutation 3, Elizabeth J Robertson
MGI ID: MGI:2388004
Synonyms: Nodaldelta, Nodaldeltanode
Gene: Nodal  Location: Chr10:61417972-61425338 bp, + strand  Genetic Position: Chr10, 32.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:79098
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExpression of the endogenous gene was reduced by the deletion of a 2.7 kb enhancer region. The targeting vector contained a floxed hygromycin cassette, which was excised in vitro via the expression of cre recombinase. In situ hybridization showed normal expression in early gastrulation stages, with attenuated expression begining during the early somite stages. Robust expression was observed in the left lateral plate mesoderm. (J:79098)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  18 strains or lines available
Original:  J:79098 Brennan J, et al., Nodal activity in the node governs left-right asymmetry. Genes Dev. 2002 Sep 15;16(18):2339-44
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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