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Tpm1tm1Dfw
Targeted Allele Detail
Nomenclature
Symbol: Tpm1tm1Dfw
Name: tropomyosin 1, alpha; targeted mutation 1, David F Wieczorek
MGI ID: MGI:2387893
Synonyms: alphaTM1-
Gene: Tpm1  Location: Chr9:67022590-67049406 bp, - strand  Genetic Position: Chr9, 36.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45833
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe striated muscle-specific exons 12 and 13 were replaced with an HPRT cassette in the reverse orientation. While the targeting construct was designed to knock-out the striated muscle isoform, the targeted allele is null. Interestingly, heterozygotes exhibit normal protein levels, despite a ~50% reduction in mRNA levels and absence of compensation by the striated muscle beta or the slow skeletal alpha isoforms, suggesting that a compensatory mechanism may operate at the translational level. (J:45833)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpm1 Mutation:  18 strains or lines available
References
Original:  J:45833 Rethinasamy P, et al., Molecular and physiological effects of alpha-tropomyosin ablation in the mouse [see comments]. Circ Res. 1998 Jan 9-23;82(1):116-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/23/2017
MGI 6.09
The Jackson Laboratory