All Phenotypes Tpm1<tm1Dfw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tpm1^tm1Dfw
targeted mutation 1, David F Wieczorek
MGI:2387893

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpm1^tm1Dfw/Tpm1^tm1Dfw	involves: 129P2/OlaHsd * Black Swiss	MGI:3623730
ht2	Tpm1^tm1Dfw/Tpm1⁺	involves: 129P2/OlaHsd * Black Swiss	MGI:3623731

Allelic Composition	Tpm1^tm1Dfw/Tpm1^tm1Dfw
Genetic Background	involves: 129P2/OlaHsd * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm1^tm1Dfw mutation (0 available); any Tpm1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:45833 )

• homozygotes die between E8 and E11.5

Allelic Composition	Tpm1^tm1Dfw/Tpm1⁺
Genetic Background	involves: 129P2/OlaHsd * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm1^tm1Dfw mutation (0 available); any Tpm1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:45833 )

• heterozygotes are viable and fertile and exhibit no abnormalities in cardiac morphology or myocardial function, as shown by normal heart rates, intraventricular pressures, and rates of contraction and relaxation as well as normal Ca²⁺ activation of myofilaments in skinned fiber bundles

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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