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Sod1tm1Dkd
Targeted Allele Detail
Nomenclature
Symbol: Sod1tm1Dkd
Name: superoxide dismutase 1, soluble; targeted mutation 1, Dipak K Das
MGI ID: MGI:2387861
Synonyms: Cu/ZnSOD-KO, Sod 1-
Gene: Sod1  Location: Chr16:90220742-90226322 bp, + strand  Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60470
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 5 and flanking intronic sequences with a neomycin resistance cassette via homologous recombination. The mutation deletes C-terminal amino acids 120-154 which constitute the structure and function of the active site channel. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of heart tissue. (J:60470)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod1 Mutation:  24 strains or lines available
References
Original:  J:60470 Yoshida T, et al., Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury. Circ Res. 2000 Feb 18;86(3):264-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory