Phenotypes associated with this allele

• Allele Symbol: Sod1^tm1Dkd
• Allele Name: targeted mutation 1, Dipak K Das
• Allele ID: MGI:2387861
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sod1^tm1Dkd/Sod1^tm1Dkd	involves: 129S1/Sv * 129X1/SvJ	MGI:3783678

Genotype
MGI:3783678

hm1

• Allelic Composition: Sod1^tm1Dkd/Sod1^tm1Dkd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardium necrosis ( J:60470 , J:89952 )

• significantly higher than in controls after ischemia (J:60470)

• extent of myocardial necrosis following ischemia and reperfusion is similar to that observed in wild-type (J:89952)

abnormal cardiovascular system physiology ( J:60470 )

• following ischemia and 30 minutes reperfusion, creatine kinase release is significantly higher from mutant hearts, and release progressively increases with reperfusion duration

decreased cardiac muscle contractility ( J:60470 )

• after 30 minutes of global ischemia, developed force (dF) in mutant hearts does not recover beyond 90% of baseline after 30 minutes of reperfusion

• significantly slower recovery of dF and dF/dT_max is observed in mutant hearts after 15 minutes of reperfusion

increased myocardial infarct size ( J:60470 )

• infarct size is significantly greater relative to wild-type and heterozygous animals after 30 minutes of global ischemia

muscle

myocardium necrosis ( J:60470 , J:89952 )

• significantly higher than in controls after ischemia (J:60470)

• extent of myocardial necrosis following ischemia and reperfusion is similar to that observed in wild-type (J:89952)

decreased cardiac muscle contractility ( J:60470 )

• after 30 minutes of global ischemia, developed force (dF) in mutant hearts does not recover beyond 90% of baseline after 30 minutes of reperfusion

• significantly slower recovery of dF and dF/dT_max is observed in mutant hearts after 15 minutes of reperfusion

homeostasis/metabolism

increased myocardial infarct size ( J:60470 )

• infarct size is significantly greater relative to wild-type and heterozygous animals after 30 minutes of global ischemia

abnormal enzyme/coenzyme level ( J:60470 )

cellular

myocardium necrosis ( J:60470 , J:89952 )

• significantly higher than in controls after ischemia (J:60470)

• extent of myocardial necrosis following ischemia and reperfusion is similar to that observed in wild-type (J:89952)

oxidative stress ( J:60470 )

• mutant hearts produce increased amounts of hydroxyl radicals following ischemia/reperfusion

• hearts produce significantly higher amounts of malonaldehyde during the postischemic period compared to controls