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Vav2tm1Kdf
Targeted Allele Detail
Nomenclature
Symbol: Vav2tm1Kdf
Name: vav 2 oncogene; targeted mutation 1, Klaus-Dieter Fischer
MGI ID: MGI:2387822
Synonyms: Vav-2-
Gene: Vav2  Location: Chr2:27152116-27317045 bp, - strand  Genetic Position: Chr2, 19.36 cM
Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat mice develop buphthalmos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69806
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ-neo cassette was fused in-frame to amino acids 150-155 of exon 5 and introduced via homologous recombination. Western blot analysis of spleen tissue from homozygous mutant animals confirmed the absence of gene expression. (J:69806)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vav2 Mutation:  28 strains or lines available
References
Original:  J:69806 Tedford K, et al., Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol. 2001 Jun;2(6):548-55
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory