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Cacna1btm1Ttan
Targeted Allele Detail
Nomenclature
Symbol: Cacna1btm1Ttan
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Tsutomu Tanabe
MGI ID: MGI:2387803
Synonyms: Cav2.2-
Gene: Cacna1b  Location: Chr2:24603887-24763152 bp, - strand  Genetic Position: Chr2, 16.58 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69585
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 with an in-frame lacZ-neo cassette. The null allele was confirmed by Northern blot, RT-PCR, and Western blot analysis of brain samples taken from homozygous mutant animals. (J:69585)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacna1b Mutation:  5 strains or lines available
References
Original:  J:69585 Saegusa H, et al., Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001 May 15;20(10):2349-56
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory