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Targeted Allele Detail
Symbol: Mertktm1Grl
Name: c-mer proto-oncogene tyrosine kinase; targeted mutation 1, Greg Lemke
MGI ID: MGI:2387765
Synonyms: Mer-, Mertk-
Gene: Mertk  Location: Chr2:128698956-128802894 bp, + strand  Genetic Position: Chr2, 62.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:54681
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exon 18 of the gene, which encodes part of the kinase domain known to be essential for tyrosine kinase function. An RNase protection assay demonstrated that a mutant transcript was expressed that lacked the deleted sequences. (J:54681)
Inheritance:    Not Specified
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mertk Mutation:  4 strains or lines available
Original:  J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
All:  31 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory