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Nudt1tm1Tts
Targeted Allele Detail
Nomenclature
Symbol: Nudt1tm1Tts
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 1; targeted mutation 1, Teruhisa Tsuzuki
MGI ID: MGI:2387695
Synonyms: MTH1-
Gene: Nudt1  Location: Chr5:140321656-140338137 bp, + strand  Genetic Position: Chr5, 78.94 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71836
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 3 and flanking intronic regions with a neomycin resistance cassette. Western blot analysis and enzyme assay of liver samples confirmed the absence of gene expression in homozygous mutant animals. (J:71836)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nudt1 Mutation:  23 strains or lines available
References
Original:  J:71836 Tsuzuki T, et al., Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11456-61
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory