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Slatm1Weis
Targeted Allele Detail
Nomenclature
Symbol: Slatm1Weis
Name: src-like adaptor; targeted mutation 1, Arthur Weiss
MGI ID: MGI:2387691
Synonyms: SLAP-
Gene: Sla  Location: Chr15:66780819-66831829 bp, - strand  Genetic Position: Chr15, 29.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71804
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of part of the promoter region and sequences encoding the first 21 amino acids with a neomycin resistance cassette. Northern blot using a probe to the C-terminal region of the gene and RT-PCR analysis of homozygous animals confirmed inactivation of the gene. Sequence analysis of a weak RT-PCR product revealed an alternatively spliced truncated transcript. (J:71804)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sla Mutation:  18 strains or lines available
References
Original:  J:71804 Sosinowski T, et al., The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 2001 Sep;15(3):457-66
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory