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Targeted Allele Detail
Symbol: Map3k14tm1Rds
Name: mitogen-activated protein kinase kinase kinase 14; targeted mutation 1, Robert D Schreiber
MGI ID: MGI:2387668
Synonyms: NIK-
Gene: Map3k14  Location: Chr11:103219764-103267401 bp, - strand  Genetic Position: Chr11, 66.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:68125
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacing the first 120 bp of exon 1 with a neomycin resistance cassette. Western blot analysis of lung, spleen, and kidney samples from homozygous mutant animals verified the null allele. (J:68125)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map3k14 Mutation:  24 strains or lines available
Original:  J:68125 Yin L, et al., Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science. 2001 Mar 16;291(5511):2162-5
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory