Map3k14^tm1Rds
Targeted Allele Detail

Summary

• Symbol: Map3k14^tm1Rds
• Name: mitogen-activated protein kinase kinase kinase 14; targeted mutation 1, Robert D Schreiber
• MGI ID: MGI:2387668
• Synonyms: NIK^-
• Gene: Map3k14 Location: Chr11:103110590-103158227 bp, - strand Genetic Position: Chr11, 66.8 cM
• Alliance: Map3k14^tm1Rds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68125
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacing the first 120 bp of exon 1 with a neomycin resistance cassette. Western blot analysis of lung, spleen, and kidney samples from homozygous mutant animals verified the null allele. (J:68125)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k14 Mutation: 41 strains or lines available

References

• Original: J:68125 Yin L, et al., Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science. 2001 Mar 16;291(5511):2162-5
• All: 31 reference(s)