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Tnfsf13btm1Msc
Targeted Allele Detail
Nomenclature
Symbol: Tnfsf13btm1Msc
Name: tumor necrosis factor (ligand) superfamily, member 13b; targeted mutation 1, Martin L Scott
MGI ID: MGI:2387426
Synonyms: BAFF-, BLyS-
Gene: Tnfsf13b  Location: Chr8:10006229-10036000 bp, + strand  Genetic Position: Chr8, 4.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71681
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-2 (732 bp of the gene) encoding the first 134 residues were replaced with a human CD2 reporter gene fused to a neomycin resistance cassette. Northern blot analysis of spleen RNA using probes to the deleted region did not detect gene transcript in homozygous mutant animals. (J:71681)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf13b Mutation:  19 strains or lines available
References
Original:  J:71681 Schiemann B, et al., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 2001 Sep 14;293(5537):2111-4
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory