Tg(CAG-CCND1)1Tera
Transgene Detail

Summary

• Symbol: Tg(CAG-CCND1)1Tera
• Name: transgene insertion 1, Masaaki Terada
• MGI ID: MGI:2387417
• Synonyms: CALNLCyclin D1
• Transgene: Tg(CAG-CCND1)1Tera Location: unknown
• Alliance: Tg(CAG-CCND1)1Tera page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-CCND1)1Tera expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCND1 (595)

  Ccnd1

  (MGI:88313)

• Mutation details: The transgenic construct consisted of a CAG promoter (chicken beta actin promoter and CMVIE enhancer) followed by a floxed neo-polyA region upstream of the human CCND1 coding region. CCND1 expression under the control of the CAG promoter only occurs after cre excision of the floxed neo-polyA cassette. Five transgenic founder lines were produced. Cre mediated recombinations were confirmed in three lines, two carrying five copies of the transgene and one carrying 10 copies. This line has five copies and was stably transmitted to the next generation. (J:75626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:75626 Yamamoto H, et al., Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res. 2002 Mar 15;62(6):1641-7
• All: 1 reference(s)