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Chemically induced Allele Detail
Symbol: CrygdAey4
Name: crystallin, gamma D; dominant cataract 4
MGI ID: MGI:2387106
Synonyms: Aey4
Gene: Crygd  Location: Chr1:65061872-65063452 bp, - strand  Genetic Position: Chr1, 32.8 cM
Morphological description and histological comparison of lenses and eyes of CrygdAey4/CrygdAey4 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C3HeB/FeJ
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA T-to-A transversion at nucleotide position 227 of the cDNA is predicted to result in a substitution of valine at position 76 with an aspartic acid in the encoded protein. This amino acid residue belongs to a structurally conserved region within the second Greek Key motif. (J:78154)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crygd Mutation:  12 strains or lines available
Original:  J:78154 Graw J, et al., V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice. Mamm Genome. 2002 Aug;13(8):452-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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