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Targeted Allele Detail
Symbol: Adcyap1tm1Nms
Name: adenylate cyclase activating polypeptide 1; targeted mutation 1, Nancy M Sherwood
MGI ID: MGI:2386973
Synonyms: PACAP-
Gene: Adcyap1  Location: Chr17:93199422-93205485 bp, + strand  Genetic Position: Chr17, 60.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:71968
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe in vitro expression of cre recombinase resulted in the excision of a floxed fragment containing all of exons 3 and 4 and a portion of exon 5. Protein was undetected in homozygous mutant mice by Western blot analysis of brain tissue. (J:71968)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:  13 strains or lines available
Original:  J:71968 Gray SL, et al., Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism. Mol Endocrinol. 2001 Oct;15(10):1739-47
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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