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Hbb-artm1.1Mkg
Targeted Allele Detail
Nomenclature
Symbol: Hbb-artm1.1Mkg
Name: hemoglobin, activating region; targeted mutation 1.1, Mark Groudine
MGI ID: MGI:2386946
Synonyms: deltaLCR
Gene: Hbb-ar  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60714
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Deletion
 
Mutation detailsThis allele is derived from Hbb-artm1Mgk. The 24 kb region of the gene containing 5' HS sites 1-6 flanked by loxP sites were removed by mating mutant animals to a cre-expressing line. Correct removal of the floxed sites was confirmed by Southern blot analysis. (J:60714)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-ar Mutation:  0 strains or lines available
References
Original:  J:60714 Bender MA, et al., Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell. 2000 Feb;5(2):387-93
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory