About   Help   FAQ
Targeted Allele Detail
Symbol: Gopctm1.1Tno
Name: golgi associated PDZ and coiled-coil motif containing; targeted mutation 1.1, Tetsuo Noda
MGI ID: MGI:2386794
Synonyms: GOPC-
Gene: Gopc  Location: Chr10:52337024-52382124 bp, - strand  Genetic Position: Chr10, 26.54 cM, cytoband B3
Ultrastructural analysis of spermatogenic cells from wild type and Gopctm1.1Tno/Gopctm1.1Tno mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:78599
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was excised from Gopctm1Tno by the in vivo expression of cre recombinase. A lacZ gene remained in place of exons 2, 2b, and 3. Neither of the two protein isoforms produced by the endogenous locus were detected in homozygous mutant mice by Western blot and immunohistochemical analyses. (J:78599)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gopc Mutation:  17 strains or lines available
Original:  J:78599 Yao R, et al., Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11211-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory