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Abcc8tm1Jbry
Targeted Allele Detail
Nomenclature
Symbol: Abcc8tm1Jbry
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8; targeted mutation 1, Joseph Bryan
MGI ID: MGI:2386677
Synonyms: Sur1-, Sur1KO
Gene: Abcc8  Location: Chr7:46104523-46180033 bp, - strand  Genetic Position: Chr7, 29.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61356
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 2 with a puromycin resistance cassette via homologous recombination. Photolabeling of neuronal membranes from homozygous mutant animals did not detect protein product. (J:61356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc8 Mutation:  38 strains or lines available
References
Original:  J:61356 Seghers V, et al., Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion. J Biol Chem. 2000 Mar 31;275(13):9270-7
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory