Phenotypes associated with this allele

• Allele Symbol: Abcc8^tm1Jbry
• Allele Name: targeted mutation 1, Joseph Bryan
• Allele ID: MGI:2386677
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc8^tm1Jbry/Abcc8^tm1Jbry	involves: 129X1/SvJ	MGI:5303087
hm2	Abcc8^tm1Jbry/Abcc8^tm1Jbry	involves: 129X1/SvJ * C57BL/6	MGI:2446456
cx3	Abcc8^tm1Jbry/Abcc8^tm1Jbry Sstr5^tm1Fcb/Sstr5^tm1Fcb	involves: 129X1/SvJ	MGI:5303086

Genotype
MGI:5303087

hm1

• Allelic Composition: Abcc8^tm1Jbry/Abcc8^tm1Jbry
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal insulin secretion ( J:179577 )

• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls

decreased insulin secretion ( J:179577 )

• insulin levels near zero

homeostasis/metabolism

abnormal insulin secretion ( J:179577 )

• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls

decreased insulin secretion ( J:179577 )

• insulin levels near zero

decreased circulating glucose level ( J:179577 )

• significantly lower glucose levels after 16 hours of fasting

increased circulating glucose level ( J:179577 )

• elevated glucose at both 30 and 60 minutes after glucose injection

Genotype
MGI:2446456

hm2

• Allelic Composition: Abcc8^tm1Jbry/Abcc8^tm1Jbry
• Genetic Background: involves: 129X1/SvJ * C57BL/6

homeostasis/metabolism

hypoglycemia ( J:61356 )

• hypoglycemic after 16 hour fast

• transient hypoglycemia at birth, reversed by day 2

impaired glucose tolerance ( J:61356 )

• mild glucose intolerance in glucose tolerance tests

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hyperinsulinemic hypoglycemia	DOID:13317	OMIM:PS256450	J:61356
transient neonatal diabetes mellitus		DOID:0060334	OMIM:601410 OMIM:610374 OMIM:610582	J:61356

Genotype
MGI:5303086

cx3

• Allelic Composition: Abcc8^tm1Jbry/Abcc8^tm1Jbry; Sstr5^tm1Fcb/Sstr5^tm1Fcb
• Genetic Background: involves: 129X1/SvJ

endocrine/exocrine glands

abnormal insulin secretion ( J:179577 )

• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls

decreased insulin secretion ( J:179577 )

• insulin levels near zero

homeostasis/metabolism

abnormal insulin secretion ( J:179577 )

• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls

decreased insulin secretion ( J:179577 )

• insulin levels near zero

decreased circulating glucose level ( J:179577 )

• significantly lower glucose levels after 16 hours of fasting compared to wild type controls

• basal levels are like wild type controls

increased circulating glucose level ( J:179577 )

• very significantly elevated glucose at both 30 and 60 minutes after glucose injection