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Vcam1tm2Flv
Targeted Allele Detail
Summary
Symbol: Vcam1tm2Flv
Name: vascular cell adhesion molecule 1; targeted mutation 2, Richard A Flavell
MGI ID: MGI:2386556
Synonyms: vcam-1flox
Gene: Vcam1  Location: Chr3:115903669-115923337 bp, - strand  Genetic Position: Chr3, 50.17 cM
Alliance: Vcam1tm2Flv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68147
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe cytokine responsive promoter region and exon 1 were left flanked by single loxP site after a floxed neo cassette was excised by in vivo expression of cre recombinase. Normal protein levels were detected in homozygous mutant mice by analysis of dendritic cells obtained from the spleen. (J:68147)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vcam1 Mutation:  42 strains or lines available
References
Original:  J:68147 Koni PA, et al., Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med. 2001 Mar 19;193(6):741-54
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory