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Gal3st1tm1Kho
Targeted Allele Detail
Nomenclature
Symbol: Gal3st1tm1Kho
Name: galactose-3-O-sulfotransferase 1; targeted mutation 1, Koichi Honke
MGI ID: MGI:2386400
Synonyms: Cst-, CST-, CSTnull
Gene: Gal3st1  Location: Chr11:3933636-3949326 bp, + strand  Genetic Position: Chr11, 2.81 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78560
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1,126 bp of the gene, including part of exon 2 and part of exon 3, was replaced with a PGK-neo cassette via homologous recombination. The targeted mutation disrupts the transmembrane domain and the 5'-3' phosphoadenosine 5'-phosphosulfate-binding motif. Northern blot analysis of brain RNA and RT-PCR analysis of testicular RNA showed that gene expression is abolished in homozygous mutant animals. (J:78560)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gal3st1 Mutation:  13 strains or lines available
References
Original:  J:78560 Honke K, et al., Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4227-32
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory