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Targeted Allele Detail
Symbol: Epas1tm1Fong
Name: endothelial PAS domain protein 1; targeted mutation 1, Guo-Hua Fong
MGI ID: MGI:2386334
Synonyms: EPAS-1
Gene: Epas1  Location: Chr17:86753864-86833410 bp, + strand  Genetic Position: Chr17, 56.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:63415
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of exon 2, which encodes the basic helix-loop-helix domain, was replaced with a cassette containing both IRES-lacZ and neo genes. Transcript was undetected by RT-PCR analyses of homozygous mutant embryos. Weak expression of beta-galactosidase, putatively due to the inefficiency of the IRES, showed the pattern of expression to recapitulate that of the endogenous gene. (J:63415)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:  46 strains or lines available
Original:  J:63415 Peng J, et al., The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8386-91
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory