Phenotypes associated with this allele

• Allele Symbol: Epas1^tm1Fong
• Allele Name: targeted mutation 1, Guo-Hua Fong
• Allele ID: MGI:2386334
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epas1^tm1Fong/Epas1^tm1Fong	involves: 129S1/Sv * 129X1/SvJ	MGI:3844976
hm2	Epas1^tm1Fong/Epas1^tm1Fong	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:3844975

Genotype
MGI:3844976

hm1

• Allelic Composition: Epas1^tm1Fong/Epas1^tm1Fong
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:63415 )

• by E11.5 most embryos are dead and by E12.5 all embryos are dead

cardiovascular system

abnormal angiogenesis ( J:63415 )

• some primary vascular beds, especially those in the eye and head, fail to undergo remodeling to form hierarchical vascular networks

abnormal vitelline vasculature morphology ( J:63415 )

• at E9.5 about 20% of embryos show severe vascular disorganization

• Background Sensitivity: defects in vascular structure are less severe on a mixed 129 and ICR background compared to mice on a 129 background

hemorrhage ( J:63415 )

• embryos surviving to E11.5 show severe hemorrhaging

embryo

abnormal vitelline vasculature morphology ( J:63415 )

• at E9.5 about 20% of embryos show severe vascular disorganization

• Background Sensitivity: defects in vascular structure are less severe on a mixed 129 and ICR background compared to mice on a 129 background

Genotype
MGI:3844975

hm2

• Allelic Composition: Epas1^tm1Fong/Epas1^tm1Fong
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

mortality/aging

postnatal lethality, incomplete penetrance ( J:63415 )

• most mice that are born alive die within 2 weeks of birth

embryonic lethality during organogenesis, incomplete penetrance ( J:63415 )

• about 2/3 of embryos die between E9.5 and E13.5 with peak lethality seen around E11.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:63415 )

• Background Sensitivity: defects in vascular structure are less severe on a mixed 129 and ICR background compared to mice on a 129 background

• subtle abnormalities, involving misarrangement of endothelial cells to form sheets rather than tubes, are detected at E11.5

hemorrhage ( J:63415 )

• at E9.5 about 10% of embryos are hemorrhagic

• many of the embryos that die prenatally display hemorrhages

• hemorrhages are seen in both the embryo proper and the yolk sac

embryo

abnormal vitelline vasculature morphology ( J:63415 )

• Background Sensitivity: defects in vascular structure are less severe on a mixed 129 and ICR background compared to mice on a 129 background

• subtle abnormalities, involving misarrangement of endothelial cells to form sheets rather than tubes, are detected at E11.5

growth/size/body

decreased birth body size ( J:63415 )

• mice born alive are smaller than control littermates